look after，take care of和care about的区别为：指代不同、用法不同、侧重点不同。
一、指代不同
1、look after：照料。
2、take care of：照看。
3、care about：在意。
二、用法不同
1、look after：用作名词时意思是“照顾”“护理”，也可指“小心”“注意”，还可指“忧虑”“挂念”，均用作不可数名词。可作“烦人的事”解，为可数名词，多用其复数形式。
2、take care of：care作“在乎，介意，关心”解时还可用作不及物动词，后面常跟介词about或for引导的短语。care只有在答句中、含有情态动词时、if从句中或定语从句中才可用于肯定句。
3、care about：care用作及物动词作“在乎”“介意”“关心”解时，后面常跟that/wh-或if/whether引导的从句，作“愿意”解时，后面常跟动词不定式，一般多用于疑问句、否定句或条件句中，也可用于含有怀疑或不确定意味的半否定句中，但不用于意思十分确切的肯定句中。
三、侧重点不同
1、look after：是行为上比较具体的照顾。
2、take care of：是比较广义的照顾。
3、care about：表示操心、关心之类。
take care of作“照顾、照料”解,相当于look after.如：
① I believe that neighbors can take care of your son while you are out.
相信我外出期间我的邻居们会照顾我的儿子的.
② The boy is very young.He can’t take care of himself.这男孩很小,不可以照顾自己.
take care of作“保管、保护”解.如：
① The teacher told the students to take care of the new books.
老师告知学生要保护好新书.
② Can you take care of your thing?你会保管你的物品吗?
★take care of与look after都能作“照顾、照料”解,可以互相替换.但look after没有“保管、保护”的意思.如：
① She stayed at home and took care of her mother yesterday.
＝She stayed at home and looked after her mother yesterday.
昨天她呆在家里照料她母亲了.
② Who is going go take care of the wounded person in the hospital?
＝Who is going to look after the wounded person in the hospital?
谁去医院照料那个受伤的人?
③ Children must take good care of their eyes.
≠Children must look after their eyes well.
孩子们要好好保护眼睛.
★take good care of和look after…well意义相同,都是“好好照料、好好照顾”的意思.
但要注意,take care of用的是good一词,而look after则用well.如：
① Don’t worry.I can take good care of your pet while you are away.
＝Don’t worry.I can look after your pet well while you are away.
放心,你不在时,我会照料好你的宠物的.
② The nurses took good care of the children.
＝The nurses looked after the children well.
保育员把孩子照料得很好.
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本回答被提问者采纳take care of 是”直接照顾“的等级。比如一件事需要做，一个病人需要照顾，这个时候使用take care of 就很恰当
Care about 是"在乎“的等级。比如你对我们国家的经济政治情况很在乎，就可以说 you care about our economic and political situations.